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Drontal Wormer for Dogs & Cats

Drontal Wormer for Dogs & Cats

  • Cat XL » Priced Per Tablet £2.49
  • Cat » Priced Per Tablet £1.79
  • Plus Flavour Bone For Dogs » Priced Per Tablet £1.79
  • Plus Flavour XL for Dogs » Priced Per Tablet £5.69
  • Puppy Suspension » 50ml Bottle £14.50
  • Puppy Suspension » 100ml Bottle £25.99

Selection of 6 products from

£1.79 to £25.99

Description

Intestinal worms, whether Roundworms or Tapeworms, can pose a potentially serious health threat to your cats if left untreated, so regular worming (every 3 months) is a necessity. In order to survive and multiply within the internal environment of your cat, worms will feed on the blood and content of the gut, with some laying dormant for up to a year within the muscle tissue, depositing an unprecedented number of eggs every day. This can lead to unpleasant symptoms of sickness, loss of appetite, diarrhoea and excessive bottom cleaning, however, sometimes worms are not accompanied by any diagnostic symptoms. Not only are worms a troublesome affliction for your cat, but they can be potentially hazardous for you if transferred through touching and licking, or picked up on your shoes and brought into the home. Drontal is an effective, economical worming treatment for dogs and cats, acting to safeguard your pet against the intrusion of harmful worms in the body, comprising an active ingredient that interferes with the energy metabolism of worms, causing them to die and pass out of the body.

Cat dosage

2 – 4kg= 1 x Drontal Cat Tablet

4 – 6kg= 1 x Drontal Cat XL Tablet

6 – 8kg= 2 x Drontal Cat Tablets

8 – 10kg= 1 x Drontal Cat & 1 x Drontal Cat XL Tablet

Dog Dosage

Dosage Guide:

½-2 kg bodyweight = ¼ Drontal Plus Flavour Tablet

2-5 kg bodyweight = ½ Drontal Plus Flavour Tablet

6-10 kg bodyweight = 1 Drontal Plus Flavour Tablet

11-15 kg bodyweight = 1½ Drontal Plus Flavour Tablet

16-20 kg bodyweight = 2 Drontal Plus Flavour Tablet

21-25 kg bodyweight = 2½ Drontal Plus Flavour Tablet

31 - 35 kg bodyweight = 1 tablet Drontal Plus XL

36 - 40 kg bodyweight = 1 Drontal Plus XL Tablet plus ½ tablet Drontal Plus Flavour

41 - 45 kg bodyweight = 1 Drontal Plus XL Tablet plus 1 tablet Drontal Plus Flavour

46 - 50 kg bodyweight = 1 Drontal Plus XL Tablet plus 1½ tablets Drontal Plus Flavour

51 - 55 kg bodyweight = 1 Drontal Plus XL Tablet plus 2 tablets Drontal Plus Flavour

56 - 60 kg bodyweight = 1 Drontal Plus XL Tablet plus 2½ tablet Drontal Plus

61 - 65 kg bodyweight = 1 Drontal Plus XL Tablet plus 3 tablets Drontal Plus Flavour

66 - 70 kg bodyweight = 2 Drontal Plus XL Tablets

Puppy Suspension

Please note, Drontal Puppy Suspension is only suitable for dogs up to one year old.

Drontal puppy suspension dosage, 1 ml per Kg bodyweight;To be given orally with or without food.

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Medication Datasheets

Cat » Priced Per Tablet

Drontal Cat Film-coated TabletsDrontal Cat XL Film-coated Tablets

Presentation

Drontal Cat Film-coated Tablets are white to yellowish, scored, coated tablets that can be divided into equal halves. Each tablet contains 230 mg pyrantel embonate and 20 mg praziquantel with 1.8 mg Titanium Dioxide (E171).

Drontal Cat XL Film-coated Tablets are unscored coated white to yellowish, ellipsoid, biconvex tablets, each containing 345 mg pyrantel embonate and 30 mg praziquantel with 2.6 mg Titanium Dioxide (E171).

Uses

For the treatment of gastrointestinal roundworms and tapeworms of cats: Toxocara cati, Toxascaris leonina, Dipylidium caninum, Taenia taeniaeformis (see ‘Further information’).

Dosage and administration

Dosage:

The recommended dose rates are 57.5 mg/kg pyrantel embonate and 5 mg/kg praziquantel. This is equivalent to one Drontal Cat Film-coated Tablet per 4 kg body weight and 1 Drontal Cat XL Film-coated Tablet per 6 kg body weight.

See dosage chart below for examples:

Weight of Cat No of Drontal Cat Film-coated Tablets No of Drontal Cat XL Film-coated Tablets
2 kg ½
4 kg 1
6 kg or 1
8 kg 2
10 kg 1 plus 1

Administration and Duration of Treatment

For single oral administration. The tablets should be given directly to the animal, but if necessary can be disguised in food.

Use During Pregnancy and Lactation

Not to be used during pregnancy but may be used during lactation.

Contra-indications, warnings, etc

Not intended for use in kittens less than 6 weeks of age.

Do not use simultaneously with piperazine compounds.

Until sufficient studies have been performed with this combination, do not use during pregnancy.

Mild and transient digestive tract disorders such as hypersalivation and/or vomiting and mild and transient neurological disorders such as ataxia may occur in extremely rare cases.

User Safety

In the interests of good hygiene, persons administering the tablets directly to a cat, or by adding them to the cat’s food, should wash their hands afterwards.

For animal treatment only. Keep out of the reach of children.

Environmental Safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 25°C.

Do not remove tablets from strip packing until required for use.

Any part-used tablets should be discarded.

Drontal Cat Film-coated Tablets: Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Drontal Cat XL Film-coated Tablets: Shelf-life of the veterinary medicinal product as packaged for sale: 4 years.

Legal category

Packaging quantities

Drontal® Cat Film-coated Tablets: Cardboard cartons with polyethylene-coated aluminium foil blisters containing 2, 24 or 96 tablets in strips of 2 or 8 tablets.
Drontal® Cat XL Film-coated Tablets : Cardboard cartons with polyethylene-coated aluminium foil blisters containing 2, 8, or 48 tablets in strips of 2 or 8 tablets.

Further information

An anthelmintic active against gastrointestinal roundworms and tapeworms. ATC VetCode: QP52 AA51. Pharmacotherapeutic Group: Anthelmintics, Praziquantel combinations. The product contains two active ingredients, pyrantel embonate (pamoate) a tetrahydropyrimidine derivative and praziquantel a partially hydrogenated pyrazino-isoquinoline derivative, used widely as an anthelmintic for both human and veterinary use.

Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow expulsion from the gastrointestinal (GI) system by peristalsis.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

In this fixed combination product, the pyrantel is active against the following ascarids: Toxocara cati, and Toxascaris leonina; the praziquantel is effective against tapeworms, in particular Dipylidium caninum and Taenia taeniaeformis.

The product has been shown to be efficacious in the control of hookworms Ancylostoma tubaeforme and A. braziliense and the tapeworm Joyeuxiella pasqualei, none of which occur naturally in cats in the UK but may occasionally be found in imported animals. Praziquantel is effective against Echinococcus multilocularis. E. multilocularis does not occur in the UK but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK, it is recommended that all dogs and cats entering the country be treated with praziquantel.

Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infection is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.

Marketing Authorisation Number

Drontal® Cat Film-coated Tablets Vm 00010/4094
Drontal® Cat XL Film-coated Tablets Vm 00010/4135

Plus Flavour Bone For Dogs » Priced Per Tablet

Drontal Plus XL Flavour Tablets for Dogs

Presentation

Drontal Plus XL Flavour Tablets are pale brown to brown oval-shaped divisible tablets scored on both sides containing 175 mg praziquantel, 504 mg pyrantel embonate and 525 mg febantel as active constituents and 408.0 mg Artificial beef flavour irradiated.

Uses

For the control of the following gastrointestinal roundworms and tapeworms of dogs and puppies.

Ascarids

Toxocara canis, Toxascaris leonina (adult and late immature forms).

Hookworms

Uncinaria stenocephala, Ancylostoma caninum (adults).

Whipworms

Trichuris vulpis (adults).

Tapeworms

Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).

Dosage and administration

For oral administration only.

The recommended dose rate is: 15 mg/kg body weight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel.

This is equivalent to 1 Drontal Plus XL Flavour Tablet per 35 kg bodyweight as follows:

Dosage Guide

Drontal Plus XL Flavour Tablets

17.5 kg body weight = ½ tablet

>17.5 - 35 kg body weight = 1 tablet

>35 - 52.5 kg body weight = 1½ tablets

>52.5 - 70 kg body weight = 2 tablets

Drontal Dog Tasty Bone Tablets should be used to achieve accurate dosing in dogs weighing less than 17.5 kg. The dose is equivalent to 1 tablet per 10 kg.

Oral administration: the tablet(s) can be given directly to the dog or disguised in food. No starvation is needed before or after treatement.

For routine treatment a single dose is recommended.

For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.

For routine control adult dogs should be treated every 3 months. In the event of heavy roundworm infection a repeat dose should be given after 14 days.

Use During Pregnancy and Lactation

Consult a veterinary surgeon before treating pregnant animals for roundworms.

The product may be used during lactation.

Do not exceed the recommended dose when treating pregnant bitches.

Contra-indications, warnings, etc

Do not use simultaneously with piperazine compounds.

Concurrent use with other cholinergic compounds is not recommended.

In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.

Drontal Plus XL Flavour Tablets are well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.

Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.

Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK or Ireland but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country be treated with praziquantel.

User safety

In case of accidental ingestion, seek medical advice and show package leaflet to the physician.

In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.

Environmental safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 25°C.

Any part-used tablets should be discarded.

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Legal category

Packaging quantities

Carton containing a PCTFE/PVC- aluminium foil strip of 2, 8 or 48 tablets.

Further information

Pharmacotherapeutic group: Anthelmintics, tetrahydropyrimidine. ATC VetCode: QP52AF30.

The product contains three active substances active against roundworms and tapeworms: 1. Febantel, a probenzimidazole, 2. Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative, 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative.

In this fixed combination product pyrantel and febantel act synergistically against relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.

The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastrointestinal (GI) system by peristalsis.

Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

Marketing Authorisation Number

Vm 00010/4153

Plus Flavour XL for Dogs » Priced Per Tablet

Drontal Plus XL Flavour Tablets for Dogs

Presentation

Drontal Plus XL Flavour Tablets are pale brown to brown oval-shaped divisible tablets scored on both sides containing 175 mg praziquantel, 504 mg pyrantel embonate and 525 mg febantel as active constituents and 408.0 mg Artificial beef flavour irradiated.

Uses

For the control of the following gastrointestinal roundworms and tapeworms of dogs and puppies.

Ascarids

Toxocara canis, Toxascaris leonina (adult and late immature forms).

Hookworms

Uncinaria stenocephala, Ancylostoma caninum (adults).

Whipworms

Trichuris vulpis (adults).

Tapeworms

Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).

Dosage and administration

For oral administration only.

The recommended dose rate is: 15 mg/kg body weight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel.

This is equivalent to 1 Drontal Plus XL Flavour Tablet per 35 kg bodyweight as follows:

Dosage Guide

Drontal Plus XL Flavour Tablets

17.5 kg body weight = ½ tablet

>17.5 - 35 kg body weight = 1 tablet

>35 - 52.5 kg body weight = 1½ tablets

>52.5 - 70 kg body weight = 2 tablets

Drontal Dog Tasty Bone Tablets should be used to achieve accurate dosing in dogs weighing less than 17.5 kg. The dose is equivalent to 1 tablet per 10 kg.

Oral administration: the tablet(s) can be given directly to the dog or disguised in food. No starvation is needed before or after treatement.

For routine treatment a single dose is recommended.

For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.

For routine control adult dogs should be treated every 3 months. In the event of heavy roundworm infection a repeat dose should be given after 14 days.

Use During Pregnancy and Lactation

Consult a veterinary surgeon before treating pregnant animals for roundworms.

The product may be used during lactation.

Do not exceed the recommended dose when treating pregnant bitches.

Contra-indications, warnings, etc

Do not use simultaneously with piperazine compounds.

Concurrent use with other cholinergic compounds is not recommended.

In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.

Drontal Plus XL Flavour Tablets are well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.

Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.

Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK or Ireland but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country be treated with praziquantel.

User safety

In case of accidental ingestion, seek medical advice and show package leaflet to the physician.

In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.

Environmental safety

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Pharmaceutical precautions

Do not store above 25°C.

Any part-used tablets should be discarded.

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

Legal category

Packaging quantities

Carton containing a PCTFE/PVC- aluminium foil strip of 2, 8 or 48 tablets.

Further information

Pharmacotherapeutic group: Anthelmintics, tetrahydropyrimidine. ATC VetCode: QP52AF30.

The product contains three active substances active against roundworms and tapeworms: 1. Febantel, a probenzimidazole, 2. Pyrantel embonate (pamoate) a tetrahydropyrimidine derivative, 3. Praziquantel, a partially hydrogenated pyrazinoisoquinoline derivative.

In this fixed combination product pyrantel and febantel act synergistically against relevant nematodes (ascarids, hookworms and whipworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.

The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular all Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against adult and immature forms of these parasites.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastrointestinal (GI) system by peristalsis.

Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

Marketing Authorisation Number

Vm 00010/4153

Puppy Suspension » 100ml Bottle

Drontal Oral Suspension for Puppies

Presentation

A pale red suspension for oral administration. Each ml of suspension contains 5.0 mg pyrantel (as pyrantel embonate 14.4 mg) and 15 mg febantel. The product also contains 2.05 mg sodium benzoate (E211), 2.05 mg sodium propionate (E281) and 0.25 mg ponceau 4R (E124).

Uses

For the treatment of roundworm infections in puppies and young dogs up to one year of age caused by:

Ascarids Toxocara canis, Toxascaris leonina
Hookworm Ancylostoma caninum, Uncinaria stenocephala
Whipworm Trichuris vulpis

Dosage and administration

The dose is 1 ml suspension/kg body weight (equivalent to 14.4 mg/kg pyrantel embonate and 15 mg/kg febantel).

Administration is by the oral route. The product may be given directly to the animal or mixed with the feed. No special dietary measures are necessary.

Mix the product by inversion of the container before withdrawing the required dose.

Through intrauterine and transmammary infection, ascarid infestation may occur in dogs at a very early age. For some animals, especially in case of severe infections, elimination of ascarids may be incomplete, and a potential risk of infections to humans can not be excluded. Where epidemiologically appropriate, it is recommended that treatment should be started at 2 weeks of age and should be performed repeatedly at suitable intervals (for example every two weeks) until weaning. Otherwise treatment should be based upon confirmed infection, for example the results of faecal examinations.

Use During Pregnancy and Lactation

This product is contra-indicated for pregnant and lactating bitches.

Contra-indications, warnings, etc

Do not use simultaneously with compounds containing piperazine.

Parasite resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.

The safety of the product has not been assessed in puppies younger than 2 weeks and weighing less than 0.6 kg.

In very rare cases mild transient digestive tract signs (e.g., vomiting, diarrhoea) may occur.

The anthelmintic effects of both pyrantel (spastic paralysis) and piperazine (neuromuscular paralysis) may be antagonised when the two drugs are used together.

Doses of up to 5 times the therapeutic level of the product have been administered to puppies and young dogs without clinical signs of intolerance arising. At 10 times the recommended dose the first sign of intolerance – vomiting – was evident.

User safety

Wash hands after use.

Avoid direct contact with the skin and eyes.

In case of accidental spillage wash the affected area immediately with clean running water.

Environmental safety

Any unused product or waste materials should be disposed of in accordance with local requirements.

Pharmaceutical precautions

This unopened veterinary medicinal product does not require any special storage conditions.

After opening, store the product at a temperature not exceeding 25 ºC.

Do not use after expiry date.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the immediate packaging: 12 weeks.

Legal category

Packaging quantities

White high density polyethylene bottles of 50 ml and 100 ml with a white polyethylene screw closure and colourless low density polyethylene adapter insert.

Devices supplied: 5ml transparent polypropylene syringe with rubber plunger.

Further information

Fixed combination of two anthelmintics: a tetrahydropyrimidine derivative, pyrantel (as the embonate) and a pro-benzimidazole, febantel. ATCvet code QP52AF02.

In this fixed combination product, the pyrantel and febantel act synergistically against nematodes (ascarids, hookworms and whipworms) of dogs. In particular, the spectrum of activity covers Toxocara canis, Ancylostoma caninum and Trichuris vulpis. Published data are also available to confirm that Toxascaris leonina and Uncinaria stenocephala are also susceptible to this particular combination of actives.

Febantel, N-{2-[2,3-bis,(methoxycarbonyl)-guanidino]-5-(phenylthio) phenyl}-2-methoxyacetamide, is a pro-benzimidazole. Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later. Pyrantel, (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine pamoate belongs to the tetrahydropyrimidine type. Its mode of action is to stimulate nicotinic cholinergic receptors inducing spastic paralysis and thereby allowing removal from the gastro-intestinal (GI) system by peristalsis.

Literature reports indicate after oral application of the recommended dose of 1 ml/kg bodyweight (corresponding to 14.4mg/kg pyrantel embonate and 15 mg/kg febantel) maximum serum concentrations for febantel were found between 1 and 6 hours with a Cmax of 0.019 mg/l two hours after dosing. As febantel, as a pro-drug, is metabolised to fenbendazole which is further converted to oxfendazole, also these metabolites were measured. Cmax of febendazole was 0.130 mg/l after 3 hours and Cmax of oxfendazole was 0.157 mg/l at about 5 hours after application.

The Cmax of pyrantel (measured as pyrantel base) was 0.084 mg/l 2.5 hours after application.

Marketing Authorisation Number

Vm 00010/4102

Puppy Suspension » 50ml Bottle

Drontal Oral Suspension for Puppies

Presentation

A pale red suspension for oral administration. Each ml of suspension contains 5.0 mg pyrantel (as pyrantel embonate 14.4 mg) and 15 mg febantel. The product also contains 2.05 mg sodium benzoate (E211), 2.05 mg sodium propionate (E281) and 0.25 mg ponceau 4R (E124).

Uses

For the treatment of roundworm infections in puppies and young dogs up to one year of age caused by:

Ascarids Toxocara canis, Toxascaris leonina
Hookworm Ancylostoma caninum, Uncinaria stenocephala
Whipworm Trichuris vulpis

Dosage and administration

The dose is 1 ml suspension/kg body weight (equivalent to 14.4 mg/kg pyrantel embonate and 15 mg/kg febantel).

Administration is by the oral route. The product may be given directly to the animal or mixed with the feed. No special dietary measures are necessary.

Mix the product by inversion of the container before withdrawing the required dose.

Through intrauterine and transmammary infection, ascarid infestation may occur in dogs at a very early age. For some animals, especially in case of severe infections, elimination of ascarids may be incomplete, and a potential risk of infections to humans can not be excluded. Where epidemiologically appropriate, it is recommended that treatment should be started at 2 weeks of age and should be performed repeatedly at suitable intervals (for example every two weeks) until weaning. Otherwise treatment should be based upon confirmed infection, for example the results of faecal examinations.

Use During Pregnancy and Lactation

This product is contra-indicated for pregnant and lactating bitches.

Contra-indications, warnings, etc

Do not use simultaneously with compounds containing piperazine.

Parasite resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.

The safety of the product has not been assessed in puppies younger than 2 weeks and weighing less than 0.6 kg.

In very rare cases mild transient digestive tract signs (e.g., vomiting, diarrhoea) may occur.

The anthelmintic effects of both pyrantel (spastic paralysis) and piperazine (neuromuscular paralysis) may be antagonised when the two drugs are used together.

Doses of up to 5 times the therapeutic level of the product have been administered to puppies and young dogs without clinical signs of intolerance arising. At 10 times the recommended dose the first sign of intolerance – vomiting – was evident.

User safety

Wash hands after use.

Avoid direct contact with the skin and eyes.

In case of accidental spillage wash the affected area immediately with clean running water.

Environmental safety

Any unused product or waste materials should be disposed of in accordance with local requirements.

Pharmaceutical precautions

This unopened veterinary medicinal product does not require any special storage conditions.

After opening, store the product at a temperature not exceeding 25 ºC.

Do not use after expiry date.

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the immediate packaging: 12 weeks.

Legal category

Packaging quantities

White high density polyethylene bottles of 50 ml and 100 ml with a white polyethylene screw closure and colourless low density polyethylene adapter insert.

Devices supplied: 5ml transparent polypropylene syringe with rubber plunger.

Further information

Fixed combination of two anthelmintics: a tetrahydropyrimidine derivative, pyrantel (as the embonate) and a pro-benzimidazole, febantel. ATCvet code QP52AF02.

In this fixed combination product, the pyrantel and febantel act synergistically against nematodes (ascarids, hookworms and whipworms) of dogs. In particular, the spectrum of activity covers Toxocara canis, Ancylostoma caninum and Trichuris vulpis. Published data are also available to confirm that Toxascaris leonina and Uncinaria stenocephala are also susceptible to this particular combination of actives.

Febantel, N-{2-[2,3-bis,(methoxycarbonyl)-guanidino]-5-(phenylthio) phenyl}-2-methoxyacetamide, is a pro-benzimidazole. Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later. Pyrantel, (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine pamoate belongs to the tetrahydropyrimidine type. Its mode of action is to stimulate nicotinic cholinergic receptors inducing spastic paralysis and thereby allowing removal from the gastro-intestinal (GI) system by peristalsis.

Literature reports indicate after oral application of the recommended dose of 1 ml/kg bodyweight (corresponding to 14.4mg/kg pyrantel embonate and 15 mg/kg febantel) maximum serum concentrations for febantel were found between 1 and 6 hours with a Cmax of 0.019 mg/l two hours after dosing. As febantel, as a pro-drug, is metabolised to fenbendazole which is further converted to oxfendazole, also these metabolites were measured. Cmax of febendazole was 0.130 mg/l after 3 hours and Cmax of oxfendazole was 0.157 mg/l at about 5 hours after application.

The Cmax of pyrantel (measured as pyrantel base) was 0.084 mg/l 2.5 hours after application.

Marketing Authorisation Number

Vm 00010/4102

Delivery Information

How quickly do you deliver?

Under almost all products on our website is an Estimated dispatch time, check this for a delivery prediction specific to the item you are looking to purchase. These badges are updated live based on the stock levels we have and also those of our suppliers - so are usually very accurate, but cannot be guaranteed. In more general terms, we aim to dispatch all orders within 1 working day of receiving payment (and a prescription if required). If we cannot do so within 3 working days we will contact you by email.

What do you charge for delivery?

For UK delivery, we charge the following:

Order Total Weight Delivery
£0-£28.99 Under 2kg £2.99
2kg+ £4.99
£29-£38.99 Under 2kg Free
2kg+ £4.99
£39+ Under 2kg Free
2kg+ Free

Prices quoted are for delivery to all parts of mainland UK except certain Scottish postcodes (where the price is higher for items sent by courier. Delivery of food abroad (including Channel Islands, N. Ireland and other islands around the UK) is charged at a higher price and free delivery is not available. Temperature controlled products, such as Insulin, are also not always subject to the standard and/or free delivery options.

For full information on our delivery charges, including prices on heavy deliveries to Scotland and abroad, see our delivery information page.

We can deliver most items to all around the world, but prices do vary. The majority of light weight orders (less than 1.5kg) can be delivered for a flat rate of £10. For an accurate estimate of the delivery charge, please put the items you require in your basket and use the "Estimate Delivery" system on the shopping basket page (you only need to enter your country and postal/zip code) for a quick quote. For deliveries to the USA you may need to go to the checkout page and enter your full address to get a quote (as some services need your state in order to quote too). For more information on international deliveries, please see our delivery information page.

Delivery of aerosols

Due to air freight restrictions aerosols cannot ever be sent abroad by Royal Mail. We appreciate your understanding.

Delivery of temperature controlled items

Some products, such as insulin and frozen food, need to be delivered in insulated packaging to prevent them from getting too warm (or too cold) during transit from us to you. Purchasing any of these items in your order will result in a £1.99 charge being added to the total to cover the high cost of the insulated packaging materials. You only pay the £1.99 once per order, regardless of how many temperature controlled items you purchase in that order.

How do I cancel or return an order?

Please call us as soon as possible if you need to amend or cancel an order on 01582 843330. If your order has been processed for dispatch we will be unable to cancel or amend the order. You will however be able to return your product for a full refund*.

To return an item, you must contact us by phone or email to arrange this BEFORE posting any product back to us. We will explain the process at this stage for you.

*For full details on returns, see our terms and conditions page.

Reviews (40)

Q & A

Below are some recent questions we've received regarding Drontal Wormer for Dogs & Cats, including answers from our team.

28 September 2015 at 7:48pm

Wormer for cats

Caroline Heaney

My cat is 6.5kg. What amount of wormer do I use and how long does it last?

  • Non-Executive Director

I would give a single Drontal XL tablet and ideally repeat this every 3 months.